ROR/NR1F Agonists

Retinoic acid-related Orphan Receptors (RORs) are a family of orphan nuclear receptors that are believed to play a role in numerous physiological processes, including circadian rhythm and bone metabolism. The endogenous ligand for these receptors is not yet known.

Three members of the ROR family have been identified: RORα, RORβ and RORγ. RORα shows the highest expression levels in the cerebellum and thalamus, whilst RORβ is expressed in a more restricted fashion in the ...