Catalog Number: 4874
Chemical Name: N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
Biological Activity
Agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from The Scripps Research Institute.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078.
    Wang et al.
    ACS Chem.Biol., 2010;5:1029
  3. Regulation of p53 stability and apoptosis by a ROR agonist.
    Wang et al.
    PLoS One, 2012;7:e34921
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