Chemical Name: N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
Biological ActivitySR 1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Regulation of p53 stability and apoptosis by a ROR agonist.
Wang et al.
PLoS One, 2012;7:e34921
Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078.
Wang et al.
ACS Chem.Biol., 2010;5:1029
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