Secretin Receptor Agonists

Secretin receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, GHRH and GIP receptors. Secretin receptors are classically localized to the epithelial cells within the pancreatic and biliary ducts, where they stimulate the release of alkaline bicarbonate-rich fluid to neutralize acidic chyme from the stomach. This protects the duodenal mucosa and provides an optimal intraluminal environment for digestion to take place.

Secretin receptors are also found in the CNS, where they are thought to play a role in the regulation of the hypothalamic-pituitary-axis (HPA) axis. The human secretin receptor gene is localized on chromosome 2p14.1.