SLITRK2 Proteins and Enzymes

SLITRK2 (Slit and Trk-like family member 2) is a transmembrane protein that is expressed in multiple regions of the brain, particularly the cerebral cortex and hippocampus. It can suppress neurite outgrowth and promote the formation of excitatory and inhibitory presynaptic structures. The synaptogenic function is dependent on the interaction of SLITRK2 with select isoforms of PTP-sigma. In humans, mutations of SLITRK6 are associated with bipolar disorder and schizophrenia.