Recombinant Human SLITRK2 Protein, CF
Recombinant Human SLITRK2 Protein, CF Summary
Thr19-Pro617, with a C-terminal 6-His tag
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 250 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
SLITRK2 (Slit and Trk-like family member 2) is an approximately 110 kDa type I transmembrane member of the SLITRK family of proteins which contain a slit-like extracellular region and (save for SLITRK1) a Trk-like cytoplasmic region (1). The extracellular domain (ECD) of mature human SLITRK2 contains 6 leucine rich repeats (LRR) followed by a C-terminal LRR domain, followed by 6 more LRR flanked by a pair of N- and C-terminal LRR domains (2, 3). Within the ECD, human SLITRK2 shares 98% amino acid sequence identity with mouse and rat SLITRK2. SLITRK2 is expressed in multiple regions of the brain, particularly the cerebral cortex and hippocampus (4). It can suppress neurite outgrowth and promote the formation of excitatory and inhibitory presynaptic structures (3-5). The synaptogenic function is dependent on the interaction of SLITRK2 with select isoforms of PTP-sigma (5, 6). In humans, mutations of SLITRK6 are associated with bipolar disorder and schizophrenia (7, 8).
- Ko, J. (2012) Mol. Cells 34:335.
- Aruga, J. et al. (2003) Gene 315:87.
- Aruga, J. and K. Mikoshiba (2003) Mol. Cell. Neurosci. 24:117.
- Yim, Y.S. et al. (2013) Proc. Natl. Acad. Sci. USA 110:4057.
- Takahashi, H. et al. (2012) Nat. Neurosci. 15:389.
- Yamagata, A. et al. (2015) Sci. Rep. 5:9686.
- Smith, E.N. et al. (2009) Mol. Pschiatry 14:755.
- Piton, A. et al. (2011) Mol. Pschiatry 16:867.
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