SRGAP2 Proteins and Enzymes

SRGAP2, also known as SLIT-ROBO Rho GTPase-activating protein 2, is a 121 kDa 1071 amino acid protein. Throughout the development of the cerebral cortex SRGAP2 has a significant role in neuronal morphogenesis. Current research on SRGAP2 is being conducted in relation to neuronitis, pilocytic astrocytoma, infantile epileptic encephalopathy and schizophrenia. SRGAP2 is linked to the long-term memory, axon guidance, localization, brain development and cell migration pathways where it interacts with FASLG, YWHAG, YWHAZ, DISC1 and MYO1G.