STING-dependent Signaling Degraders

STING (stimulator of interferon genes) is a pattern recognition receptor and adapter protein that is anchored in the endoplasmic reticulum (ER), and is highly expressed in immune cells. STING-dependent signaling mediates a Toll-like receptor independent innate immune response following detection of cytoplasmic pathogens.

The invasion of a cell by a pathogen, such as a virus or bacterium, results in a host defence response mediated by the adapter protein STING. Foreign DNA is detected by ...