3 results for "STING/TMEM173 Small Molecules and Peptides" in Products
STING/TMEM173 Small Molecules and Peptides
STING (stimulator of interferon genes) is encoded by the TMEM173 gene and is an adaptor molecule involved in the activation of innate immune responses to PAMPS (pathogen-associated molecular patterns) and DAMPS (damage-associated molecular patterns). STING specifically recognizes cytosolic DNA products derived from pathogens (e.g., cytomegalovirus, vaccinia virus, Listeria monocytogenes or dead cells (1, 2). In the STING pathway, dsDNA derived from pathogens or damaged cells serves as a ...
Selective inhibitor of cyclic GMP-AMP synthase (cGAS)
| Chemical Name: | Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate |
| Purity: | ≥98% |
Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)
| Alternate Names: | RU320521 |
| Chemical Name: | 3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone |
| Purity: | ≥98% |
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
| Chemical Name: | 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide |
| Purity: | ≥98% |
