RU.521

Tocris Bioscience | Catalog # 7904

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)
Tocris Bioscience

Key Product Details

Description

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Alternative Names

RU320521
View all Synthase/Synthetase Inhibitors »

Product Description

RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM; IC50 values are 0.11 μM and 2.94 μM against m-cGAS and h-cGAS, respectively). RU.521 suppresses dsDNA-activated reporter activity but not 5'ppp-HP20 RNA or murine IFN-β-induced IFN-β1-dependent gene expression. RU.521 reduces constitutive expression of type I interferon in primary macrophages from a mouse model of Aicardi-Goutières syndrome. Pretreatment of chimeric antigen receptor (CAR) redirected T cells with RU.521 increases efficiency of virus-free gene editing by improving cell viability and CAR integration in cell line.

Product Specifications for RU.521

Molecular Weight

415.23

Formula

C19H12Cl2N4O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone

CAS Number

2262452-06-0

InChI Key

VIQXILLOJLATEF-UHFFFAOYSA-N

SMILES

O=C1OC(C=2C=CC=CC12)C3=C(O)N(N=C3C)C4=NC=5C=CC(Cl)=C(Cl)C5N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.76 50

Preparing Stock Solutions for RU.521

The following data is based on the product molecular weight 415.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.82 mL 24.08 mL 48.17 mL
2.5 mM 0.96 mL 4.82 mL 9.63 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
25 mM 0.10 mL 0.48 mL 0.96 mL

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Product Documents for RU.521

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RU.521

For research use only

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