Transglutaminase 4/TGM4 Proteins and Enzymes

The principal activity of transglutaminases (TGMs) is to catalyze the Ca²⁺-dependent formation of an isopeptide bond between the gamma-carboxamide group of a glutaminyl residue and the epsilon-amino group of a lysyl residue. TGMs can also catalyze the attachment of polyamines to the gamma-carboxamide group of a glutaminyl residue and the deamidation of glutaminyl residues. Several TGMs have also been shown to possess protein disulfide isomerase activity. Protein aggregates in the brain are a ...