TRPM Channel Compounds

The melastatin-related receptor family (TRPM) is the largest subfamily of the transient receptor potential (TRP) superfamily of ion channels. It contains 8 known members, subdivided into 4 groups, which perform a range of functions including detection of taste and osmolarity, and control of cell proliferation.

Members of the TRPM subfamily are grouped on the basis of sequence homology. The first subgroup includes TRPM1 and TRPM3; the second, TRPM6 and TRPM7; the third, TRPM2 and TRPM8; and the ...