UNG Proteins and Enzymes

UNG (Uracil DNA N-Glycosylase) is one of four known human DNA N-glycosylases involved in the removal of uracil from DNA. It is a monofunctional enzyme that initiates base excision repair (BER) by hydrolyzing the N-glycosidic bond between the uracil base and the sugar-phosphate backbone in DNA. The resultant abasic, or AP site, generated by this cleavage is repaired in subsequent steps of the BER process.