Azurin p28 peptide

Tocris Bioscience | Catalog # 7662

Increases p53 levels; binds p53 and inhibits COP1-mediated ubiquitination of p53
Tocris Bioscience
Discontinued Product
7662 has been discontinued. View all p53 products.

Key Product Details

Description

Increases p53 levels; binds p53 and inhibits COP1-mediated ubiquitination of p53
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Product Description

Azurin p28 peptide is a 28 amino acid fragment of azurin (amino acids 50-77). The peptide is preferentially taken up by human breast cancer cell lines via caveolin-mediated endocytosis. Azurin p28 peptide binds wild-type and mutant p53 protein and inhibits E3 ligase COP1-mediated ubiquitination of p53 by >80%, resulting in decreased proteasomal degradation of p53. It induces cell cycle arrest in the G2/M phase leading to apoptosis. Azurin p28 peptide exhibits antiproliferative effects in human breast cancer cells in vitro and in vivo.

Product Specifications for Azurin p28 peptide

Molecular Weight

2914.20

Formula

C122H197N31O47S2

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

897026-25-4

PubChem ID

53363312

InChI Key

RFGPECAMUVWTJN-AWHPYGDNSA-N

SMILES

O=C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in 0.01M PBS

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Background References

References are publications that support the biological activity of the product.

Product Documents for Azurin p28 peptide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Azurin p28 peptide

For research use only

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