B7-1/CD80 Antibody (16C10) - Azide and BSA Free

Name: B7-1/CD80 Antibody (16C10) - Azide and BSA Free
Brand: Novus Biologicals
SKU: NBP3-12026
Price: 219 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-12026

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

ELISA, Block/Neutralize

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Lambda Clone # 16C10

Format

Azide and BSA Free

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Product Specifications

Immunogen

This antibody was generated by immunization of cynomolgus monkeys with human B7.1 antigen.

Specificity

This antibody binds human B7-1/CD80 and inhibits the B7.1:CD28 pathway.

Clonality

Monoclonal

Host

Human

Isotype

IgG1 Lambda

Applications for B7-1/CD80 Antibody (16C10) - Azide and BSA Free

Application

Recommended Usage

Block/Neutralize

Optimal dilutions of this antibody should be experimentally determined.

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

0.02% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

Background: B7-1/CD80

The B-lymphocyte activation antigen B7-1 (CD80) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines (1). The relatively small CTLA-4/B7-1 binding interface exhibits an unusually high degree of shape complementarity. CTLA-4 forms homodimers through a newly defined interface of highly conserved residues. This zipper-like oligomerization provides the structural basis for forming unusually stable signalling complexes at the T-cell surface, underscoring the importance of potent inhibitory signalling in human immune responses (2).

Alternate Names

B71, CD80

Gene Symbol

CD80

Additional B7-1/CD80 Products

Product Documents for B7-1/CD80 Antibody (16C10) - Azide and BSA Free

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Certificate of Analysis

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Product Specific Notices for B7-1/CD80 Antibody (16C10) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.