BQ-123

Tocris Bioscience | Catalog # 1188

Selective ETA antagonist
Tocris Bioscience

Key Product Details

Description

Selective ETA antagonist
View all Endothelin ETA Receptor Antagonists »

Product Description

BQ-123 is a selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.

Product Specifications for BQ-123

Molecular Weight

611.00

Formula

C31H42N6O7

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

136553-81-6

PubChem ID

52943236

InChI Key

VYCMAAOURFJIHD-AOYLRGCGSA-N

SMILES

CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 0.4mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 41 publications citing the usage of this product.

Product Documents for BQ-123

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BQ-123

For research use only

Customer Reviews for BQ-123 (1)

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  • Great Product
    Name: Anonymous
    Assay Type: Ex Vivo
    Verified Customer | Posted 11/02/2017
    We utilized this product at 1uM to inhibit endothelin-A receptors ex vivo in mouse aortas followed by conducting vasomotor function experiments. We utilized this ET-A inhibitor in combination with Tocris' BQ788 (endothelin-B receptor antagonist) which works equally as well. We have obtained high quality data using this BQ123 product!
    BQ-123 1188

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