COP Antibody - Azide and BSA Free

Novus Biologicals | Catalog # H00114769-B01P

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Format

Azide and BSA Free
View all COP Primary Antibodies »

Product Specifications

Immunogen

COP1 (NP_443121.1, 1 a.a. - 97 a.a.) full-length human protein. MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAGPIPGN

Specificity

COP1 - caspase-1 dominant-negative inhibitor pseudo-ICE,

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for COP Antibody - Azide and BSA Free

Western Blot: COP Antibody [H00114769-B01P]

Western Blot: COP Antibody [H00114769-B01P]

Western Blot: COP Antibody [H00114769-B01P] - Analysis of CARD16 expression in transfected 293T cell line by CARD16 polyclonal antibody. Lane 1: COP1 transfected lysate(10.67 KDa). Lane 2: Non-transfected lysate.
Immunocytochemistry/ Immunofluorescence: COP Antibody [H00114769-B01P]

Immunocytochemistry/ Immunofluorescence: COP Antibody [H00114769-B01P]

Immunocytochemistry/Immunofluorescence: COP Antibody [H00114769-B01P] - Analysis of purified antibody to COP1 on HeLa cell. (antibody concentration 10 ug/ml)

Applications for COP Antibody - Azide and BSA Free

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: COP

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of theproteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release ofIL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokineresponse. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, andstaurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspasesCASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2

Alternate Names

CARD only domain-containing protein 1, CARD only protein, caspase recruitment domain family, member 16, Caspase-1 inhibitor COP, COP1caspase-1 dominant-negative inhibitor pseudo-ICE, COPcaspase recruitment domain-containing protein 16, EC 3.4.22.36, Pseudo interleukin-1 beta converting enzyme, pseudo interleukin-1beta converting enzyme, PSEUDO-ICE

Entrez Gene IDs

114769 (Human)

Gene Symbol

CARD16

UniProt

NP_443121.1 (Human)

Additional COP Products

Product Documents for COP Antibody - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for COP Antibody - Azide and BSA Free

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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