CoraFluor™ 2, Haloalkane
Tocris Bioscience | Catalog # 8818
Key Product Details
Description
Product Description
CoraFluor™ 2, Haloalkane is a cell permeable terbium-based time-resolved Förster resonance energy transfer (TR-FRET) donor for live cell TR-FRET assay development, such as target engagement and ternary complex assays. CoraFluor™ 2, Haloalkane is designed with a chloroalkane ligand for reactivity with haloalkane dehalogenase labeled proteins. CoraFluor™ 2, Haloalkane can be used in live cell intracellular TR-FRET assays. It is exceptionally bright, providing unmatched assay sensitivity and stability in biological media over other commercially available TR-FRET donors. CoraFluor™ 2, Haloalkane displays red shifted excitation and is excitable by both 365 nm and 405 nm lasers. It is compatible with common acceptor dyes such as FAM/FITC, AF488, GFP, mCherry, TMR and Cyanine 5, SE (Cat. No. 5436), enabling seamless assay integration in high throughput screening applications.
CoraFluor™ 1, Haloalkane, CoraFluor™ 1, thiol reactive, CoraFluor™ 1, amine reactive and CoraFluor™ 2, amine reactive also available.
For more information, please see our CoraFluor™ TR-FRET technology flyer .
CoraFluor™ is a trademark of Bio-Techne Corp.
Scientific Data Images for CoraFluor™ 2, Haloalkane
Live cell TR-FRET assay.
Cellular dose-dependent inhibition of HDAC1-dehalogenase fusion protein labeled with CoraFluor™ 2, Haloalkane in HEK293T cells by various HDAC inhibitors (treatment for 4 h at 37 °C, 1 μM SAHA-NCT).Licensing Information
Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254Optical Data
| λabs | 356 nm |
| Extinction Coefficient (ε) | 15900 M-1cm-1 |
| Quantum Yield (φ) | 0.35 |
| Closest Laser line | 337 nm |
| Cell Permeable | Yes |
| Application | Time-resolved fluorescence energy transfer (TR-FRET) |
Product Specifications for CoraFluor™ 2, Haloalkane
Molecular Weight
Storage
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Background References
References are publications that support the biological activity of the product.
- Payne Bright and stable luminescent probes for target engagement profiling in live cells. Nat.Chem.Biol. 2021 PMID: 34675420
Product Documents for CoraFluor™ 2, Haloalkane
Product Specific Notices for CoraFluor™ 2, Haloalkane
For research use only
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