D-AP5

Tocris Bioscience | Catalog # 0106

Potent and selective NMDA receptor antagonist; more active form of DL-AP5
Tocris Bioscience

Key Product Details

Description

Potent and selective NMDA receptor antagonist; more active form of DL-AP5

Alternative Names

2-APV,D-APV,D-2-amino-5-phosphonovalerate
View all NMDA Receptor Antagonists »

Product Description

D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 is the more active isomer of DL-AP5 (Cat. No. 0105) and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection, D-AP5 results in rapid reduction of NMDA-response but no effect on spontaneously active neurons.

DL Mixture, L-isomer and sodium salt also available.

Product Specifications for D-AP5

Molecular Weight

197.13

Formula

C5H12NO5P

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

D-(-)-2-Amino-5-phosphonopentanoic acid

CAS Number

79055-68-8

PubChem ID

135342

InChI Key

VOROEQBFPPIACJ-SCSAIBSYSA-N

SMILES

N[C@@]([H])([C@](O)=O)CCCP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.71 100

Preparing Stock Solutions for D-AP5

The following data is based on the product molecular weight 197.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.07 mL 25.36 mL 50.73 mL
5 mM 1.01 mL 5.07 mL 10.15 mL
10 mM 0.51 mL 2.54 mL 5.07 mL
50 mM 0.10 mL 0.51 mL 1.01 mL

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Product Documents for D-AP5

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for D-AP5

For research use only

Customer Reviews for D-AP5 (8)

4.4 out of 5
8 Customer Ratings
5 Stars
38%
4 Stars
63%
3 Stars
0%
2 Stars
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1 Stars
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Showing  1 - 5 的 8 reviews Showing All
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  • Good at blocking NMDA receptor activity
    Name: Krish K
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Neurons
    Verified Customer | Posted 09/11/2025
    Incubate overnight
    50 micromolar APV treated overnight on neuronal cultures rescued glutamate toxicity.
    D-AP5 0106
  • Neuron glia culture
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Mixed neuron-glia
    Verified Customer | Posted 07/12/2020
    Incubate for 24h
    D-AP5 (100 μM)
    D-AP5 0106
  • Validation
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    10 μM for 2 h
    D-AP5 0106
  • Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/03/2020
    10uM D-AP5
    D-AP5 0106
  • Works as intended
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 05/14/2019
    We delivered this drug intracranially in combination with DNQX to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.
  • Validation
    Name: Kevin Xu
    Species: Mouse
    Cell Line/Tissue: Lung
    Verified Customer | Posted 01/04/2018
    Good reproducibility
  • product review
    Name: Harika Vemula
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/04/2018
    in in-vivo studies
  • NMDA antagonist
    Name: Anonymous
    Assay Type: In Vivo
    Verified Customer | Posted 07/17/2017
    NMDA antagonist

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Showing  1 - 5 的 8 reviews Showing All