L-AP5

Tocris Bioscience | Catalog # 0107

Potent and selective NMDA antagonist; less active form of DL-AP5
Tocris Bioscience

Key Product Details

Description

Potent and selective NMDA antagonist; less active form of DL-AP5
View all NMDA Receptor Antagonists »

Product Description

L-AP5 is an NMDA antagonist and an agonist at quisqualate-sensitized AP6 site, where it is more potent than the isomer D-AP5. L-AP5 is more potent than D-AP5 at depressing synaptic responses at amino acid-induced and synaptic excitation of cat spinal neurons.

D-isomer, DL mixture and sodium salt also available.

Product Specifications for L-AP5

Molecular Weight

197.13

Formula

C5H12NO5P

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

L-(+)-2-Amino-5-phosphonopentanoic acid

CAS Number

79055-67-7

PubChem ID

1617110

InChI Key

VOROEQBFPPIACJ-BYPYZUCNSA-N

SMILES

[H][C@@](CCCP(O)(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for L-AP5

The following data is based on the product molecular weight 197.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.07 mL 25.36 mL 50.73 mL
5 mM 1.01 mL 5.07 mL 10.15 mL
10 mM 0.51 mL 2.54 mL 5.07 mL
50 mM 0.10 mL 0.51 mL 1.01 mL

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Product Documents for L-AP5

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-AP5

For research use only

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  • AP5 decreases neuronal acitvity
    Name: Luiz Alexandre Magno
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Brain
    Verified Customer | Posted 10/26/2018
    AP5 is an NMDA antagonist, so we have used it to block the function of neurons. Neuronal activity of animals injected with AP5 into the brain were decreased, seen as low expression of the protein CFOS.
    L-AP5 0107

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