FC 11

Tocris Bioscience | Catalog # 7306

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
View all Active Degraders »

Product Description

FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC® Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

FAK antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4467 and MAB4467.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for FC 11

Molecular Weight

949.92

Formula

C41H42F3N13O9S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide

CAS Number

2271035-37-9

PubChem ID

154723926

InChI Key

RZKZQCHSKWKOAJ-UHFFFAOYSA-N

SMILES

CN(S(C)(=O)=O)C1=C(C=CC=N1)CNC2=NC(NC3=CC=C(C=C3)NC(C4=CN(N=N4)CCOCCOCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=NC=C2C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 94.99 100

Preparing Stock Solutions for FC 11

The following data is based on the product molecular weight 949.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.05 mL 5.26 mL 10.53 mL
5 mM 0.21 mL 1.05 mL 2.11 mL
10 mM 0.11 mL 0.53 mL 1.05 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for FC 11

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FC 11

For research use only

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