Fumagillin

Key Product Details

Product Description

Fumagillin is an antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.

Product Specifications for Fumagillin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Fumagillin

The following data is based on the product molecular weight 458.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.025 mM	87.23 mL	436.16 mL	872.31 mL
0.125 mM	17.45 mL	87.23 mL	174.46 mL
0.25 mM	8.72 mL	43.62 mL	87.23 mL
1.25 mM	1.74 mL	8.72 mL	17.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Rodriguez-Nieto A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 2001 PMID: 11848509
• Ingber Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 1990 PMID: 1701033
• Jaronski Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 1972 PMID: 4630977
• Lowther The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9770455

Product Documents for Fumagillin