Human AICDA Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB39102R Datasheet / COA / SDS

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FAB39102R-100UG

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Human AICDA Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human AICDA in direct ELISAs.

Source

Monoclonal Rat IgG2a Clone # 359218

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human AICDA
Met1-Leu198
Accession # Q9GZX7

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: AICDA

AICDA, also known as AID, is a 24 kDa cytidine deaminase that converts deoxycytidine to deoxyuridine in single stranded DNA. Its expression is restricted to activated lymph node and tonsillar B cells and is required for terminal B cell differentiation. Loss of function mutations of AICDA cause severe humoral immunodeficiency by preventing immunoglobulin class switching and somatic hypermutation. Human AICDA shares 92% - 95% amino acid sequence identity with bovine, canine, and mouse AICDA.

Long Name

Activation-Induced Cytidine Deaminase

Entrez Gene IDs

57379 (Human); 11628 (Mouse); 399679 (Rat)

Alternate Names

activation-induced cytidine deaminase; AICDA; AID; AIDCytidine aminohydrolase; Arp2; CDA2; HIGM2; HIGM2EC 3.5.4.5; integrated into Burkitt's lymphoma cell line Ramos