Human ATAD2 Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB9169T Datasheet / COA / SDS

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FAB9169T-100UG

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Human ATAD2 Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human ATAD2 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 952947

Purification

Protein A or G purified

Immunogen

Human ATAD2 synthetic peptide
Accession # Q6PL18

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: ATAD2

ATAD2/ANCCA/PRO2000 is an AAA (ATPases Associated with diverse cellular Activities) protein with two AAA domains and a bromodomain. ATAD2 is a coactivator in the regulatory process of ER alpha induction of target genes in breast cancer. Upon activation by estrogen, ATAD2 associates with ER alpha and ACTR and subsequently promotes expression of ER alpha target genes cyclin D1, c-myc and E2F1 in breast cancer cells. ATAD2 also binds and hydrolyzes ATP, mediating hypermethylation of protein complexes. ATAD2 is reported to be a prognostic biomarker in endometrial, lung, ovarian and gastric cancers. The function of ATAD2 has also been reported in other carcinomas, including cervical, hepatocellular, colorectal and lung cancers.

Long Name

ATPase family, AAA domain containing 2

Entrez Gene IDs

29028 (Human); 70472 (Mouse); 314993 (Rat)

Alternate Names

AAA nuclear coregulator cancer-associated protein; ANCCA; ANCCAMGC131938; ATAD2; ATPase family AAA domain-containing protein 2; ATPase family, AAA domain containing 2; CT137; DKFZp667N1320; EC 3.6.1.3; MGC142216; MGC29843; MGC5254; PRO2000