Human FGF-10 Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: FGF-10

The FGFs are a growing family of heparin-binding growth factors that show a variety of biological activities toward cells of mesenchymal, neuronal and epithelial origin. All FGFs have two conserved cysteine residues and share significant amino acid sequence homology. FGF-10 was originally identified from rat embryos by homology-based polymerase chain reaction. Human and mouse FGF-10 were subsequently cloned. The human FGF-10 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human FGF-10 shares approximately 92% and 95% amino acid sequence identity with mouse and rat FGF‑10, respectively. Among the FGF family members, FGF-10 is most closely related to FGF-7. The expression of FGF-10 transcripts has been shown to be most abundant in the embryo and adult lung. Recombinant FGF-10 preparations have been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. Based on its in vitro biological activities and in vivo expression pattern, FGF-10 has been proposed to play unique roles in the brain, in lung development, wound healing and limb bud formation.

Product Datasheets

Related Research Areas

• FGF Family
• FGF Ligands
• gamma delta T Cells
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