Human FOLR2 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB5697R Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB5697R-100UG

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Human FOLR2 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human FOLR2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human FOLR1, 3, 4, or recombinant mouse FOLR2 is observed.

Source

Monoclonal Mouse IgG2b Clone # 583121

Purification

Protein A or G purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human FOLR2
Gln22-His228
Accession # P14207

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FOLR2

Folate Receptor 2 (FOLR2), also known as Folate Receptor beta, is a 38 kDa glycoprotein that is anchored to the membrane via glycosyl phosphatidylinositol. It mediates the cellular uptake of dietary folates that are required for key steps in amino acid metabolism. FOLR2 is predominantly expressed in placenta, myeloid cells, and some CD34⁺ hematopoietic progenitor cells. It is upregulated on some cancer cells and at sites of chronic inflammation. Human FOLR2 shares 83% amino acid sequence identity with mouse and rat FOLR2.

Long Name

Folate Receptor 2

Entrez Gene IDs

2350 (Human); 14276 (Mouse); 293154 (Rat)

Alternate Names

beta-HFR; FBP; FBP/PL-1; folate receptor 2 (fetal); Folate receptor 2; folate receptor beta; folate receptor, beta; Folate receptor, fetal/placental; folate-binding protein, fetal/placental; FOLR2; FR-beta; FR-P3; Placental folate-binding protein