Human HIF-2 alpha /EPAS1 Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: HIF-2 alpha/EPAS1

The hypoxia-inducible transcription factor 2 alpha (HIF-2 alpha ) is stabilized in hypoxic tissue and, similarly to HIF-1 alpha, complexes with Aryl hydrocarbon receptor nuclear translocator (ARNT). Both the HIF-1 and HIF-2 complexes bind hypoxia-response elements (HREs) in the promoters of many genes involved in adapting to an environment of insufficient oxygen or hypoxia. HIF-1 and HIF-2 do not appear completely redundant. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the potentially broad impact of gene regulation by both HIF-1 alpha and HIF-2 alpha

Product Datasheets

Related Research Areas

• Basic Helix-Loop-Helix (bHLH) Transcription Factors
• Cancer Biomarkers
• Cancer Stem Cell Markers
• Cancer Stem Cell Transcription Factors
• Epigenetics
• HIF Transcription Factors
• Intracellular Signaling Molecules in Angiogenesis
• Transcription Factors in the Akt Pathway
• Transcription Regulators in VSMC
• Transcriptional Regulators in Allergy and Asthma