Human HOXD10 Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: HOXD10

HOXD10 is a sequence-specific transcription factor that belongs to the Abd-B homeobox family.  It is a nuclear protein that is expressed in developing limb buds and is involved in differentiation and limb development.  HOXD10 mutations have been associated with foot deformities such as rocker-bottom foot and the deformity seen in Charcot-Marie-Tooth disease.  HOXD10 also functions as a candidate tumor suppressor.  In gastric cancer there is downregulation in gastric cancer tissues and cell lines relative to normal stomach tissues.  It has also been reported to suppress ovarian cancer, hepatocellular carcinoma and other cancer cells. Re-expression of HOXD10 results in significant inhibition of cell survival, induction of cell apoptosis and impairment of cell migration and invasion.

Product Datasheets

Related Research Areas

• Cancer Biomarkers
• Homeodomain (Hox) Transcription Factors