Human LAP (TGF-beta 1) Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: LAP (TGF-beta 1)

The TGF‑ beta family includes several related proteins (70‑80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF‑ beta 1, TGF‑ beta 2, TGF‑ beta 1.2, TGF‑ beta 3, TGF‑ beta 4, and TGF‑ beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF‑ beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF‑ beta family members are naturally associated with their own distinct LAPs.

Product Datasheets

Related Research Areas

• Airway Inflammation and Remodeling
• Cytokines and Receptors in Angiogenesis
• gamma delta T Cells
• Multiple Sclerosis and Myelin Related Molecules
• Myeloid-derived Suppressor Cells (MDSC)
• Platelet Cytokine and Growth Factor Receptors
• T Cell Cytokine Signaling
• TGF-beta Family
• TGF-beta Family Ligands
• Th17 Cells
• Th22 Cells
• Th9 Cells