Human LCoR Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB7534V Datasheet / COA / SDS

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FAB7534V-100UG

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Human LCoR Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human LCoR in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 731229

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human LCoR
Asn110-Gln338
Accession # Q96JN0

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: LCoR

LCoR (ligand-dependent corepressor), also known as MLR2 (Mblk1-related protein 2), is a 47-50 kDa nuclear phosphoprotein that is a corepressor of ligand-dependent transcriptional activation by nuclear receptors such as estrogen and progesterone receptors. It is widely expressed throughout fetal development and in the adult. The 433 amino acid (aa) LCoR contains two N-terminal PxDLS nuclear receptor interaction motifs, a central HDAC interaction motif, a nuclear localization signal, and a C‑terminal Helix-Turn-Helix motif. Alternate splicing produces a truncated 406 aa variant. Within the region used as an immunogen, human LCoR shares 97% aa identity with mouse and rat LCoR.

Long Name

Ligand-dependent Nuclear Receptor Corepressor

Entrez Gene IDs

84458 (Human); 212391 (Mouse); 365462 (Rat)

Alternate Names

FLJ38026; KIAA1795RP11-175O19.1; LCoR; ligand dependent nuclear receptor corepressor; Mblk1-related protein 2; MLR2; MLR2ligand-dependent corepressor