Human/Mouse GATA-2 Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: GATA-2

GATA factors constitute a family of transcriptional regulatory factors that bind to the consensus DNA sequence (A/T) GATA (A/G) to control diverse tissue-specific programs of gene expression and morphogenesis. GATA-1/2/3 are each expressed in the hematopoietic system while GATA 4/5/6 are each expressed in the developing heart and in gastrointestinal and gut-derived tissues. Specifically, GATA-2 is expressed in hematopoietic progenitors and stem cells. GATA-2 expression is associated with cell proliferation. GATA-2 is 480 amino acids in length and contains 2 Zn finger domains responsible for DNA binding (aa 295‑319 and 349‑373). Over aa 15‑279 human GATA-2 share 96% identity with mouse GATA-2.

Product Datasheets

Related Research Areas

• Cancer Stem Cell Transcription Factors
• GATA Transcription Factors
• Hematopoietic Stem Cell Markers
• Hematopoietic Stem Cell Transcription Factors and Regulators
• Neural Stem Cell Markers
• Pluripotent Stem Cell Transcription Factors
• Transcription Factors in the Akt Pathway