Human/Mouse/Rat PLC-gamma 1 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB32881V Datasheet / COA / SDS

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FAB32881V-100UG

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Human/Mouse/Rat PLC-gamma 1 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects endogenous human, mouse, and rat PLC-gamma 1.

Source

Monoclonal Rat IgG2a Clone # 479819

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PLC-Î³1
Phe550-His663
Accession # P19174

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PLC-gamma 1

PLC-gamma 1 (phospholipase C-gamma 1) cleaves the polar head group from the membrane lipid phosphatidyl-inositol 4,5-biphosphate. The consequence of this reaction is the generation of two secondary messengers, inositol 1,4,5-trisphosphate and diacylglycerol, which mediate the mobilization of intracellular calcium and the activation of protein kinase C, respectively. Members of the PLC family are regulated by different signaling pathways. PLC-gamma 1 is regulated through receptor and non-receptor tyrosine kinases, while the PLC-beta isoforms are regulated by G-protein coupled receptors.

Long Name

Phospholipase C gamma 1

Entrez Gene IDs

5335 (Human); 18803 (Mouse); 25738 (Rat)

Alternate Names

EC 3.1.4.11; gamma 1 (formerly subtype 148); monophosphatidylinositol phosphodiesterase; NCKAP3,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; PLC11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; PLC148; PLC-148; PLCG1; PLCgamma 1; PLC-gamma 1; PLC-gamma-1; PLC-II1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; PPLCA; triphosphoinositide phosphodiesterase