Human ROR-beta Antibody (Clone N7927)

R&D Systems | Catalog # PP-N7927-00

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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Mouse, Ferret, Rabbit, Transgenic Mouse

Applications

Validated:

Western Blot, Direct ELISA

Cited:

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # N7927
View all ROR beta/NR1F2 Primary Antibodies »

Product Specifications

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human ROR-beta Antibody (Clone N7927)

Application
Recommended Usage

Direct ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Background: ROR beta/NR1F2

Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer. An alternatively spliced isoform, ROR beta2, has been isolated from rats, and the expression of ROR beta2 is confined to the pineal gland and retina. ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but is characterized by a different amino-terminal domain. ROR beta expression has been documented in various regions of the mouse brain. ESTs have been isolated from human tissue libraries, including cancerous human kidney and normal brain, pineal and eye.

Long Name

Retinoic Acid-Related Orphan Receptor beta

Alternate Names

NR1F2, RORB, RZRB

Entrez Gene IDs

6096 (Human)

Gene Symbol

RORB

Additional ROR beta/NR1F2 Products

Product Documents for Human ROR-beta Antibody (Clone N7927)

Certificate of Analysis

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Product Specific Notices for Human ROR-beta Antibody (Clone N7927)

For research use only

Citations for Human ROR-beta Antibody (Clone N7927)

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