SARM1 (Sterile alpha and TIR motif-containing protein 1; also SAM domain-containing protein 2 and TIR-1 homolog) is a 73-75 kDa member of the TLR adaptor family of molecules. It is both nuclear and cytoplasmic, and expressed in monocytes, neurons, and retinal photoreceptor cells, where it demonstrates disparate activities. In monocytes, SARM1 is a specific inhibitor of TRIF-dependent TLR-3 and -4 signaling, and appears to block MAPK phosphorylation. In neurons, SARM1 regulates microtubule stability, and thus axon and dendrite elongation. And in retinal photoreceptor cells, SARM1 complexes with Na/K ATPase to create a cell surface receptor for retinoschisin. Human SARM1 is 724 amino acids (aa) in length. It contains an N-terminal polybasic motif (aa 1-20) and a Gly-rich region (aa 22-90) that may anchor the molecule to intracellular membranes. It also possesses two SAM domains (aa 412-548) plus a TIR region (aa 559-657) that appears to interact with TIRF. Proteolytic cleavage products of 35 kDa and 30 kDa have been described. There is one splice variant that shows a 72 aa substitution for aa 1-106. Over aa 556-724, human SARM1 shares 94% aa identity with mouse SARM1.
Human SARM1 Alexa Fluor® 594‑conjugated Antibody
R&D Systems | Catalog # FAB7037T
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Lys556-Thr724
Accession # Q6SZW1
Specificity
Clonality
Host
Isotype
Applications for Human SARM1 Alexa Fluor® 594‑conjugated Antibody
Immunocytochemistry
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: SARM1
Long Name
Alternate Names
Gene Symbol
UniProt
Additional SARM1 Products
Product Documents for Human SARM1 Alexa Fluor® 594‑conjugated Antibody
Product Specific Notices for Human SARM1 Alexa Fluor® 594‑conjugated Antibody
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only
Customer Reviews for Human SARM1 Alexa Fluor® 594‑conjugated Antibody
There are currently no reviews for this product. Be the first to review Human SARM1 Alexa Fluor® 594‑conjugated Antibody and earn rewards!
Have you used Human SARM1 Alexa Fluor® 594‑conjugated Antibody?
Submit a review and receive an Amazon gift card!
$25/€18/£15/$25CAN/¥2500 Yen for a review with an image
$10/€7/£6/$10CAN/¥1110 Yen for a review without an image
Submit a review
Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
- Appropriate Fixation of IHC/ICC Samples
- Cellular Response to Hypoxia Protocols
- Detection & Visualization of Antibody Binding
- ICC Cell Smear Protocol for Suspension Cells
- ICC Immunocytochemistry Protocol Videos
- ICC for Adherent Cells
- Immunocytochemistry (ICC) Protocol
- Immunocytochemistry Troubleshooting
- Immunofluorescence of Organoids Embedded in Cultrex Basement Membrane Extract
- Immunohistochemistry (IHC) and Immunocytochemistry (ICC) Protocols
- Preparing Samples for IHC/ICC Experiments
- Preventing Non-Specific Staining (Non-Specific Binding)
- Primary Antibody Selection & Optimization
- Protocol for VisUCyte™ HRP Polymer Detection Reagent
- Protocol for the Fluorescent ICC Staining of Cell Smears - Graphic
- Protocol for the Fluorescent ICC Staining of Cultured Cells on Coverslips - Graphic
- Protocol for the Preparation and Fluorescent ICC Staining of Cells on Coverslips
- Protocol for the Preparation and Fluorescent ICC Staining of Non-adherent Cells
- Protocol for the Preparation and Fluorescent ICC Staining of Stem Cells on Coverslips
- Protocol for the Preparation of a Cell Smear for Non-adherent Cell ICC - Graphic
- TUNEL and Active Caspase-3 Detection by IHC/ICC Protocol
- The Importance of IHC/ICC Controls
- View all Protocols, Troubleshooting, Illustrated assays and Webinars