Human TDAG8/GPR65 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB10077V Datasheet / COA / SDS

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FAB10077V-100UG

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All TDAG8/GPR65 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human TDAG8/GPR65 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human TDAG8/GPR65 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 976128

Purification

Protein A or G purified

Immunogen

NS0 mouse myeloma cell line transfected with human TDAG8/GPR65
Met1-Glu337
Accession # Q8IYL9

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TDAG8/GPR65

Human G Protein-Coupled Receptor 65 (GPR65), also known as T-Cell Death-Associated Gene 8 Protein (TDAG8) and Psychosine Receptor, is a 337 aminoacids proton-sensing GPCR primarily expressed in lymphoid tissues and is uniquely expressed in Th17 cells; mice deficient in GPR65 are resistant to autoimmunity. GPR65 senses pH by protonation of histidine residues on its extracellular domain. Many pH-sensing G protein-coupled receptors have emerged as potential therapeutic agents in conditions that involve the response to acidotic stress.

Long Name

G Protein-coupled Receptor 65

Entrez Gene IDs

8477 (Human); 14744 (Mouse); 299242 (Rat)

Alternate Names

G protein-coupled receptor 65; GPR65; G-protein coupled receptor 65; Psychosine Receptor; T-cell death-associated gene 8 protein; TDAG8; TDAG8hTDAG8