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Human TIMP Luminex Performance Assay 4-plex Kit

Catalog #: LKT003 Datasheet / COA / SDS
The magnetic TIMP Assay is still available, catalog # LKTM003

Discontinued Product

LKT003 has been discontinued.
View all TIMP Assay Kits products.

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R&D Systems Luminex High Performance Panel - Magnetic
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Citations (8)
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Human TIMP Luminex Performance Assay 4-plex Kit Summary

Assay Type bead-based multiplex assay for the Luminex® platform
Format 1 x 96-well microplate and antibody-coated beads
Analytes Detected Please see analyte list in assay customization tool below.
Performance Validation Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

Not finding your analyte of interest? View our complete Luminex offering in the full version of our Luminex Assay Customization Tool. We also offer Custom Luminex Services.

Which Luminex Assay is right for me?

Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: TIMP Assay Kits

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

Long Name
Tissue Inhibitors of Metalloproteinases 1
Alternate Names
TIMP Assay Kits

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Product Specific Notices
Luminex® is a registered trademark of Luminex Corporation.

Citations for Human TIMP Luminex Performance Assay 4-plex Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. Circulating mediators of inflammation and immune activation in AIDS-related non-hodgkin lymphoma.
    Authors: Nolen B, Breen E, Bream J, Jenkins F, Kingsley L, Rinaldo C, Lokshin A
    PLoS ONE, 2014-06-12;9(6):e99144.
    Species: Human
    Sample Types: Serum
  2. Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort study.
    Authors: Nolen B, Brand R, Prosser D, Velikokhatnaya L, Allen P, Zeh H, Grizzle W, Huang Y, Lomakin A, Lokshin A
    PLoS ONE, 2014-04-18;9(4):e94928.
    Species: Human
    Sample Types: Serum
  3. Serum CA19-9, cathepsin D, and matrix metalloproteinase-7 as a diagnostic panel for pancreatic ductal adenocarcinoma.
    Proteomics, 2012-12-01;12(23):3590-7.
    Species: Human
    Sample Types: Serum
  4. Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial disease.
    Authors: Anuradha R, George JP, Pavankumar N, Kumaraswami V, Nutman TB, Babu S
    PLoS Negl Trop Dis, 2012-06-05;6(6):e1681.
  5. MMP-1 drives immunopathology in human tuberculosis and transgenic mice.
    Authors: Elkington P, Shiomi T, Breen R, Nuttall RK, Ugarte-Gil CA, Walker NF, Saraiva L, Pedersen B, Mauri F, Lipman M, Edwards DR, Robertson BD, D'Armiento J, Friedland JS
    J. Clin. Invest., 2011-04-25;121(5):1827-33.
    Species: Human
    Sample Types: Sputum
  6. Circulating matrix metalloproteinases in infective endocarditis: a possible marker of the embolic risk.
    Authors: Thuny F, Habib G, Le Dolley Y, Canault M, Casalta JP, Verdier M, Avierinos JF, Raoult D, Mege JL, Morange PE, Alessi MC
    PLoS ONE, 2011-04-14;6(4):e18830.
    Species: Human
    Sample Types: Serum
  7. Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis.
    Authors: Li X, Meng J, Qiao X
    J. Allergy Clin. Immunol., 2010-04-14;125(5):1061-8.
    Species: Human
    Sample Types: Tissue Homogenates
  8. Development of a multimarker assay for early detection of ovarian cancer.
    Authors: Yurkovetsky Z, Skates S, Lomakin A, Nolen B, Pulsipher T, Modugno F, Marks J, Godwin A, Gorelik E, Jacobs I, Menon U, Lu K, Badgwell D, Bast RC, Lokshin AE
    J. Clin. Oncol., 2010-04-05;28(13):2159-66.
    Species: Human
    Sample Types: Serum

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