Human TORC3 Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB9455T Datasheet / COA / SDS

Recombinant Monoclonal Antibody

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FAB9455T-100UG

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human TORC3 Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human TORC3 in direct ELISAs.

Source

Monoclonal Rabbit IgG Clone # 2069D

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human TORC3
Ser425-Asn574
Accession # Q6UUV7

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TORC3

CREB-Regulated Transcription Coactivator 3 (CRTC3), also known as TORC3, a transcriptional coactivator for CREB1, acts as a coactivator in the SIK/TORC signaling pathway. Dephosphorylated CRTC3 increases the interaction of CREB1 cAMP response element (CRE) sites. CRTC3 activity is important in regulating the expression of genes involved in cellular energy metabolism. Its binding to the HTLV-1 protein Tax enhances HTLV-1 transcription, whereas its binding to cellular Bcl3 inhibits HTLV-1 transcription. CRTC3 polymorphism have been associated with obesity and hypertriglyceridemia.

Long Name

Transducer of Regulated CREB-binding Protein 3

Entrez Gene IDs

64784 (Human); 70461 (Mouse); 365297 (Rat)

Alternate Names

CREB regulated transcription coactivator 3; CRTC3; FLJ21868; TORC3; TORC-3; TORC3CREB-regulated transcription coactivator 3; Transducer of CREB protein 3; transducer of regulated cAMP response element-binding protein (CREB) 3; Transducer of regulated cAMP response element-binding protein 3; transducer of regulated CREB protein 3