Human Transglutaminase 7/TGM7 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB5426V Datasheet / COA / SDS

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FAB5426V-100UG

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Human Transglutaminase 7/TGM7 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Transglutaminase 7/TGM7 in direct ELISAs and Western blots. In direct ELISAs, no cross‑reactivity with recombinant human TGM2, 3, 4, or recombinant mouse TGM2 is observed.

Source

Monoclonal Rat IgG2a Clone # 602708

Purification

Protein A or G purified

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Transglutaminase 7/TGM7
Asp2-Pro710
Accession # Q96PF1

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Transglutaminase 7/TGM7

Transglutaminase 7 (TGM7), also known as protein-glutamine gamma -glutamyltransferase Z, TGase Z and TGZ, is an 80 kDa, widely expressed member of the Transglutaminase superfamily and family. Human Transglutaminase 7 is 710 amino acids (aa) in length and contains a Transglutaminase family, C-terminal Ig like domain (aa 608‑705). Human Transglutaminase 7 shares 78% aa identity with mouse Transglutaminase 7. Like other Transglutaminases, Transglutaminase 7 is an enzyme that stabilizes protein assembly through the formation of intra- or intermolecular N epsilon ( gamma -glutamyl)lysine bonds. It catalyzes a calcium-dependent transferase reaction between the gamma -carboxamide group of a peptide-bound glutamine residue and various primary amines, most commonly the epsilon -amino group of lysine residues.

Entrez Gene IDs

116179 (Human); 640543 (Mouse); 691932 (Rat)

Alternate Names

protein-glutamine gamma-glutamyltransferase Z; TG(Z); TGase Z; TGase-7; TGM7; TGMZ; TGMZEC 2.3.2.13; TGZ; Transglutaminase 7; Transglutaminase Z; transglutaminase-7