Human Transthyretin/Prealbumin Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB7505G Datasheet / COA / SDS

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FAB7505G-100UG

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Human Transthyretin/Prealbumin Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Transthyretin/Prealbumin in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG1 Clone # 760430

Purification

Protein A or G purified

Immunogen

Human Transthyretin/Prealbumin

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Transthyretin/Prealbumin

Transthyretin (TTR), previously called thyroxin-binding prealbumin, is a 55 kDa homotetramer of 14-15 kDa monomers that is found in plasma. TTR is responsible for the transport of the thyroid hormone T4 and retinol binding protein (RBP). It slows renal clearance of T4 and RBP due to megalin-mediated re-uptake of TTR complexes in the renal tubules. TTR is also found in tissues including the brain. Numerous human polymorphisms have been associated with aggregates found in familial amyloidotic polyneuropathies (FAP). Mature human TTR shares 80% and 83% amino acid sequence identity with mouse and rat TTR, respectively.

Entrez Gene IDs

7276 (Human)

Alternate Names

ATTR; HsT2651; PALB; PALBTBPA; Prealbumin; prealbumin, amyloidosis type I; TBPA; thyroxine-binding prealbumin; Transthyretin; TTR