Human UFM1 Antibody

UFM1 ( Ubiquitin-fold modifier 1) is a 9.1 kDa ubiquitin-like protein, displaying a similar tertiary structure to ubiquitin. The UFM1 conjugation system is a novel Ubiquitin-like (Ubl) system whose physiological target(s) and biological functions remain largely undefined. To be activated, UFM1 is processed C-terminally by two specific proteases, UfSP1 and UfSP2.  After processing, UFM1 is activated via the E1 enzyme, UBA5, and then conjugated by the E2 enzyme, UFC1. UFL1 has been identified as the E3 enzyme. However, cellular functions associated with target proteins that are modified by UFM1 are still unknown. Genetic study has demonstrated that the Ufm1-activating enzyme Uba5 is indispensible for erythroid differentiation in mice, highlighting the importance of this novel system in animal development. It was found that the UFM1 system was transcriptionally up-regulated by disturbance of the ER homeostasis and inhibition of vesicle trafficking.