IGF-I R/IGF1R [p Tyr1166] Antibody (24GB13670)

Novus Biologicals | Catalog # NBP3-50917

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB13670
View all IGF-I R/IGF1R Primary Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Phospho-IGF-I R/IGF1R (Tyr1166) (Uniprot: P08069)

Modification

p Tyr1166

Specificity

This antibody detects endogenous levels of IGF1R only when phosphorylated at Y1166

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for IGF-I R/IGF1R [p Tyr1166] Antibody (24GB13670)

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IGF-I R/IGF1R

The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival

Long Name

Insulin-like Growth Factor I Receptor

Alternate Names

CD221, IGF-1R, IGF-IR, IGF1R, IGFIR

Gene Symbol

IGF1R

Additional IGF-I R/IGF1R Products

Product Documents for IGF-I R/IGF1R [p Tyr1166] Antibody (24GB13670)

Certificate of Analysis

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Product Specific Notices for IGF-I R/IGF1R [p Tyr1166] Antibody (24GB13670)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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