KRpep-2d

Tocris Bioscience | Catalog # 7928

Potent and selective KRASG12D inhibitor
Tocris Bioscience
Discontinued Product
7928 has been discontinued. View all Ras products.

Key Product Details

Description

Potent and selective KRASG12D inhibitor
View all Ras »

Product Description

KRpep-2d is a potent KRAS inhibitor. Selective for G12D mutant KRAS over wild type KRAS (IC50 = 1.6 nM and 42 nM respectively). Allosterically binds to KRAS to block interaction with substrate, such as GDP. Cell permeable and suitable for use in vitro.

Product Specifications for KRpep-2d

Molecular Weight

2561.03

Formula

C108H182N44O25S2

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

2098181-84-9

InChI Key

PNSDZPKWIOBSHR-WVEXBLHFSA-N

SMILES

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)NC1=O)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CC(O)=O)C(N5[C@@H](CCC5)C(N[C@H]1C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(NC(C)=O)=N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for KRpep-2d

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KRpep-2d

For research use only

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