Müllerian inhibiting substance (MIS), also named anti-Müllerian hormone (AMH), is a tissue-specific TGF-beta superfamily growth factor. Its expression is restricted to Sertoli cells of fetal and postnatal testis, and to granulosa cells of postnatal ovary. MIS is synthesized and secreted as a disulfide-linked homodimeric propeptide. Proteolytic cleavage is required to separate the N-terminal proregion from the C-terminal bioactive peptide. Both fragments remain associated in a non-covalent complex. The C-terminal sequence forms a cysteine knot via seven canonical cysteine residues found in TGF-beta superfamily members.
MIS/AMH Antibody (213828) [CoraFluor™ 1]
Novus Biologicals | Catalog # FAB17374CL1
![MIS/AMH Antibody (213828) [CoraFluor™ 1]](https://resources.rndsystems.com/images/products/fab17374cl1_mouse-mis-amh-mab-213828-corafluor-1-269202517321516.png "Product Feature: CoraFluor Probes for TR-FRET")
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Key Product Details
Species Reactivity
Human
Applications
ELISA
Label
CoraFluor 1
Antibody Source
Monoclonal Mouse IgG1 Clone # 213828
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Product Specifications
Immunogen
E. coli-derived recombinant human MIS/AMH
Ala453-Arg560
Accession # NP_000470
Ala453-Arg560
Accession # NP_000470
Specificity
Detects human MIS/AMH in direct ELISAs.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Description
This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
Scientific Data Images for MIS/AMH Antibody (213828) [CoraFluor™ 1]
Product Feature: CoraFluor Probes for TR-FRET
CoraFluor™ 1, amine reactive (Catalog:7920) and CoraFluor™ 2, amine reactive (Catalog # 7950) are terbium-based probes that have been developed for use as TR-FRET donors. They emit wavelengths compatible with commonly used fluorescent acceptor dyes such as BODIPY® (or BDY) and Janelia Fluor® dyes, FITC (Catalog # 5440), TMR and Cyanine 5 (Catalog # 5436). CoraFluor™ fluorescence is brighter and more stable in biological media than existing TR-FRET donors, leading to enhanced sensitivity and improved data generation. CoraFluor™ 1 exhibits excitation upon exposure to a 337 nm UV laser.Applications for MIS/AMH Antibody (213828) [CoraFluor™ 1]
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Recommended applications are based on validated applications from the unconjugated base product MAB17374. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
PBS
Preservative
No Preservative
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark. Do not freeze.
Background: MIS/AMH
Long Name
Mullerian-inhibiting Substance/Anti-Mullerian Hormone
Alternate Names
AMH
Additional MIS/AMH Products
Product Documents for MIS/AMH Antibody (213828) [CoraFluor™ 1]
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for MIS/AMH Antibody (213828) [CoraFluor™ 1]
Sold for research purposes only under agreement from Massachusetts General Hospital, US Patent No. 12,134,721. A license is required for development of new commercial assay platforms (e.g., microarrays, microfluidics), diagnostic use or other unlicensed uses. Please contact Technical Support for further details: techsupport@bio-techne.com.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
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- View all Protocols, Troubleshooting, Illustrated assays and Webinars
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