Mouse c-Rel Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: c-Rel

c-Rel/Rel, the cellular counterpart of the v-Rel oncogene of the avian reticuloendotheliosis retrovirus, is a 69 kDa class II member of the Rel/NK-kappa B family of transcription factors. All Rel family members contain a RHD (Rel homology domain) that is involved in dimerization, DNA and I kappa B binding, and nuclear localization. Class II members contain an additional C-terminal transcriptional activation segment. Rel both homodimerizes and heterodimerizes with multiple family members. Following dimerization, Rel complexes initiate transcription by acting on decameric DNA motifs termed kappa B binding sites. The important role of c-Rel in B-cell development, growth, and survival is well documented. c-Rel is also involved in responses to auto-antigens, allo-antigens, allergens and pathogens and may contribute to the development of certain human lymphoid cell cancers.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• C-type Lectin Receptors
• IL-1 Family
• IL-17 Family
• Immunoglobulin-Like Domain Transcription Factors
• Interferons
• Natural Killer T (NKT) Cells
• NFkB Pathway
• NOD-like Receptors and the Inflammasome
• Regulatory T Cells (Tregs)
• RIG-I-like Receptors
• TNF Superfamily Regulators
• Toll-Like Receptors
• Transcription Factors and Regulators
• Transcription Factors in the Akt Pathway