PAK2 Antibody (677411) [Biotin]

Name: PAK2 Antibody (677411) [Biotin]
Brand: Novus Biologicals
SKU: FAB6849B
Price: 539 USD
Availability: InStock

Novus Biologicals | Catalog # FAB6849B

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Biotin

Antibody Source

Monoclonal Mouse IgG₃ Clone # 677411

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Product Specifications

Immunogen

E. coli-derived recombinant human PAK2
Leu127-Gln221
Accession # Q13177

Specificity

Detects human PAK2 in direct ELISAs. In direct ELISAs, approximately 5% cross‑reactivity with recombinant human (rh) PAK1 and no cross-reactivity with rhPAK1B, 3, 4, 6, or 7 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₃

Applications for PAK2 Antibody (677411) [Biotin]

Application

Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PAK2

p21-activated kinase 2 (PAK2) is a member of a family of serine/threonine protein kinase defined by their interaction with the small GTPases, Cdc42 and Rac (1-2). The PAK proteins can be essentially divided into two categories, groups I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK5 and PAK6), based on their structures (3). All six PAKs play an important role in diverse cellular processes, including cytoskeletal dynamics, growth/apoptotic signal transduction through MAP kinases, and regulation of transcription factors (4). The ubiquitous PAK-2 is unique among the PAK isoforms because it is also activated through proteolytic cleavage by caspases or caspase-like proteases (5). Full-length PAK-2 is localized in the cytoplasm, whereas the proteolytic PAK-2p34 fragment translocates to the nucleus. Activation of full-length PAK-2 stimulates cell survival, whereas proteolytic activation of PAK-2p34 is involved in programmed cell death (6).

Long Name

p21-activated Kinase 2

Alternate Names

gamma-PAK, PAK65, S6/H4 Kinase

Gene Symbol

PAK2

Additional PAK2 Products

Product Documents for PAK2 Antibody (677411) [Biotin]

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Product Specific Notices for PAK2 Antibody (677411) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.