PDGF-BB (Platelet-Derived Growth Factor BB) is a homodimeric molecule expressed by hepatocytes and nonresorbing osteoclasts, and it promotes osteoblast development and bone formation. It is also produced by platelets, macrophages, and mast cells. At sites of injury, it promotes neutrophil and macrophage infiltration for debridement, fibroblast secretion of new extracellular matrix, and IGF-I-mediated re-epithelialization. The traditional receptor for PDGF is either a homodimer or heterodimer created from two type I transmembrane RTKs, PDGF R alpha and PDGF R beta. PDGF-BB has been shown to bind the alpha/alpha homodimer, alpha/beta heterodimer, and the beta/beta homodimer in vitro, and act through the beta/beta homodimer in vivo.
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PDGF-BB Antibody Pair [Biotin]
Novus Biologicals | Catalog # NBP3-57748
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Key Product Details
Assay Type
Sandwich ELISA
Sample Type
Cell culture supernatants from horses (Equus caballus). Can also be used in additional biological sample types reported in the literature reported in the literature, including serum, plasma, platelet-rich plasma, synovial fluid, wound exudates, and tissue lysates, with minor protocol modifications recommended to optimize assay performance across different matrices. (100 ul)
Reactivity
Equine
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Product Specifications
Description
The ELISA kit contains a capture antibody, detection antibody, and recombinant protein standard validated to function together in an optimized ELISA format; kit components are not supplied in matched quantities and may be purchased separately. This product is for research use only.
Sample Volume Required
100 ul
Conjugate
Biotin
Preparation and Storage
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Storage of components varies. See protocol for specific instructions.
Background: PDGF-BB
Long Name
Platelet-derived Growth Factor BB
Alternate Names
PDGFBB
Gene Symbol
PDGFB
Additional PDGF-BB Products
Product Documents for PDGF-BB Antibody Pair [Biotin]
Certificate of Analysis
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Product Specific Notices for PDGF-BB Antibody Pair [Biotin]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.
Related Research Areas
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