PRIMA-1^MET

Key Product Details

Product Description

PRIMA-1^MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

Product Specifications for PRIMA-1^MET

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PRIMA-1^MET

The following data is based on the product molecular weight 199.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

7 6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.02 mL	25.09 mL	50.19 mL
5 mM	1.00 mL	5.02 mL	10.04 mL
10 mM	0.50 mL	2.51 mL	5.02 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Shen PRIMA-1^MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 2008 PMID: 18663359
• Stuber PRIMA-1^MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol.Cancer 2009 PMID: 19323829
• Bykov PRIMA-1^MET synergizes with cisp. to induce tumor cell apoptosis. Oncogene 2005 PMID: 15735745

Product Documents for PRIMA-1^MET