RCM 1

Key Product Details

Product Description

RCM 1 is a forkhead box M1 (FOXM1) transcription factor inhibitor (IC₅₀ = 0.72 μM). Inhibits expression of FOXM1 target genes. Induces FOXM1 protein degradation in vitro. Reduces airway resistance, increases lung compliance and decreases proinflammatory cytokine production in allergen-exposed mice.

Product Specifications for RCM 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RCM 1

The following data is based on the product molecular weight 424.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.78 mL	58.88 mL	117.76 mL
1 mM	2.36 mL	11.78 mL	23.55 mL
2 mM	1.18 mL	5.89 mL	11.78 mL
10 mM	0.24 mL	1.18 mL	2.36 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sun The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci.Signal. 2017 PMID: 28420758

Product Documents for RCM 1