STF 118804

Tocris Bioscience | Catalog # 5207

NAMPT inhibitor; depletes leukemia stem cells
Tocris Bioscience
Discontinued Product
5207 has been discontinued. View all NAMPT Inhibitors products.

Key Product Details

Description

NAMPT inhibitor; depletes leukemia stem cells
View all NAMPT Inhibitors »

Product Description

STF 118804 is a NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.

Product Specifications for STF 118804

Molecular Weight

461.53

Formula

C25H23N3O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide

CAS Number

894187-61-2

PubChem ID

20916937

InChI Key

DLFCEZOMHBPDGI-UHFFFAOYSA-N

SMILES

O=C(C2=CC=C(C3=NC(CS(C4=CC=C(C)C=C4)(=O)=O)=C(C)O3)C=C2)NCC1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.15 100

Preparing Stock Solutions for STF 118804

The following data is based on the product molecular weight 461.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for STF 118804

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for STF 118804

For research use only

Customer Reviews for STF 118804 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used STF 118804?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 的 1 review Showing All
Filter By:
Clear Filters X
  • It works well for cell culture.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: human astrocytes
    Verified Customer | Posted 05/07/2020
    After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.
    STF 118804 5207

There are no reviews that match your criteria.

Showing  1 - 1 的 1 review Showing All