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4 results for "NAMPT Inhibitors" in 产品
NAMPT Inhibitors
PBEF, also called Nampt or visfatin, is a ubiquitous 52 kDa nicotinamide phosphoribosyltransferase. PBEF is the rate-limiting component in the biosynthesis of NAD+, and functions in the cytoplasm to regulate energy metabolism during stress responses and immune activation. Although it lacks a signal sequence, PBEF appears to be secreted by visceral ...
Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-1-((S)-18-(tert-Butyl)-1,16-dioxo-1-(4-((4-((4-(3-(pyridin-3-ylmethyl)thioureido)phenyl)sulfonyl)piperazin-1-yl)methyl)phenyl)-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% |
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NAMPT inhibitor; active in vivo and cytotoxic
| Chemical Name: | N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine |
| Purity: | ≥98% |
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Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
| Chemical Name: | (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide |
| Purity: | ≥98% |
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NAMPT inhibitor; also GLUT1 inhibitor
| Chemical Name: | 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide |
| Purity: | ≥98% |
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