Cell Adhesion Antagonists

Cellular adhesion molecules (CAMs) are a large family of transmembrane proteins that link the cytoskeleton and intracellular signaling cascades with the extracellular environment. Cell adhesion molecules have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer.

There are four major families of cell adhesion molecules:

1. Immunoglobulin Superfamily (IgSF) CAMs - bind to integrins and members of this ...